منابع مشابه
Cell Biology: DUBing CP110 Controls Centrosome Numbers
Accurate control of centrosome number is critical for the maintenance of genomic integrity. A recent study reveals that the deubiquitinating enzyme USP33 regulates centrosome biogenesis by stabilizing the centriolar protein CP110.
متن کاملCentrosome Biology: A SAS-sy Centriole in the Cell Cycle
A novel protein in Caenorhabditis elegans, SAS-4, is a component of centrioles and is required for centriole duplication. Depletion of SAS-4 results in stunted centrioles and a smaller centrosome, suggesting a link to organelle size control.
متن کاملRegulation of the cell cycle and centrosome biology by deubiquitylases
Post-translational modification of proteins by ubiquitylation is increasingly recognised as a highly complex code that contributes to the regulation of diverse cellular processes. In humans, a family of almost 100 deubiquitylase enzymes (DUBs) are assigned to six subfamilies and many of these DUBs can remove ubiquitin from proteins to reverse signals. Roles for individual DUBs have been delinea...
متن کاملCentrosome Biology: The Ins and Outs of Centrosome Assembly
As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
متن کاملFanni Gergely: Exploring centrosome biology
JCB • VOLUME 215 • NUMBER 3 • 2016 294 Encouraged by her parents to study abroad, Fanni Gergely left Budapest, Hungary, for Peterhouse College at the University of Cambridge, UK, with the intention to study theoretical physics. To her surprise, she developed an interest for experimental sciences during an internship with Simon Maddrell, which was further confi rmed by a short stay in Daniel St....
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ژورنال
عنوان ژورنال: Science
سال: 2002
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.298.5597.1303c